منابع مشابه
ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress
ATR controls chromosome integrity and chromatin dynamics. We have previously shown that yeast Mec1/ATR promotes chromatin detachment from the nuclear envelope to counteract aberrant topological transitions during DNA replication. Here, we provide evidence that ATR activity at the nuclear envelope responds to mechanical stress. Human ATR associates with the nuclear envelope during S phase and pr...
متن کاملUV and genotoxic stress induce ATR relocalization in mouse spermatocytes.
During meiosis, phosphorylation of H2AX is one of the earliest cellular responses to the generation of DNA double-strand breaks (DSBs) by the SPO11 topoisomerase. ATM is the kinase which mediates the formation of phosphorylated H2AX (H2AX) meiotic foci, while ATR is the kinase which signals chromosome asynapsis at the level of the XY bivalent. To investigate the possible role of ATR also in DN...
متن کاملRPA and ATR link transcriptional stress to p53.
The mechanisms by which DNA-damaging agents trigger the induction of the stress response protein p53 are poorly understood but may involve alterations of chromatin structure or blockage of either transcription or replication. Here we show that transcription-blocking agents can induce phosphorylation of the Ser-15 site of p53 in a replication-independent manner. Furthermore, microinjection of an...
متن کاملOncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR.
Oncogenic Ras and p53 loss-of-function mutations are common in many advanced sporadic malignancies and together predict a limited responsiveness to conventional chemotherapy. Notably, studies in cultured cells have indicated that each of these genetic alterations creates a selective sensitivity to ataxia telangiectasia and Rad3-related (ATR) pathway inhibition. Here, we describe a genetic syste...
متن کاملSomesthetic senses.
This is a review of recent advances in our understanding of the sensory modalities of touch, temperature sensitivity, and pain. Most of the research described is psychophysical or perceptual in nature, but physiological and imaging studies are included when they sharpen issues or reveal underlying mechanisms. Coverage of touch research comprises the subjects of acuity, vibrotaction and texture ...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2014
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm3864